This is a 6-to-9 month on-site contractor position in Lebanon, NH, with no guarantee of extension or transfer to FTE.

We are seeking a self-motivated and experienced Scientist to join our research team located in Lebanon, New Hampshire to pioneer the next generation of antibody-targeted siRNA/ASO therapeutics for chronic inflammatory and autoimmune diseases. This is an opportunity to do meaningful work in a fast-paced start-up environment where scientific contributions are highly visible, valued, and impact the company’s strategic direction. The ideal candidate has earned a Ph.D. in immunology, biochemistry, or an equivalent scientific discipline. Experience with in vitro studies with human immune cells including cell isolation, culture, characterization by flow cytometry is essential. Proficiency expected with immunological cell-based assays including Th1/Th2 and M1/M2 assays and strong technical and documentation skills required. The successful candidate is a great team player who will play a key role in the characterization of new conjugated therapeutics, mechanisms of action and proof of concept studies, contributing to advancing our pipeline programs.

Key Responsibilities

This is a hands-on scientific role to develop and characterize antibody drug conjugates with responsibilities that include:

Develop, establish, and perform immunological assays (cell culture, functional assays and flow cytometry) to support hit-to-lead (H2L) and lead optimization.
Participate in tissue collection and downstream cell-based assays.
Generate and communicate high-quality, well-documented data to support real-time decisions.
Maintain accurate documentation and ensuring data integrity.
Proactively communicate project status, anticipate potential issues, and recommend appropriate resource decisions.
Collaborate cross-functionally with internal teams and external partners to advance project goals.

Qualifications

The ideal candidate has Ph.D. in Biochemistry, Molecular Biology, Immunology or an equivalent scientific discipline, or MS with ≥4 years’ experience in a biotech/pharma.

The candidate should have experience in working in or with the following areas:

Proficiency in using a wide range of laboratory techniques including extensive experience in basic immunological techniques such as immune cell isolation, flow cytometry, T/B/myeloid cell functional assays including Th1/Th2 T cell assays, and ELISA
Experience with nucleic acid biology and the effect of nucleic acid manipulation (e.g., reporter assays, ASO or siRNA approaches, qRTPCR)

Candidate will also have:

Strong problem-solving skills and scientific curiosity
Ability to be a self-starter and thrive in a fast-paced, small company environment
Goal-oriented mindset with a high level of accountability and initiative
Excellent communication, attention to detail and interpersonal skills
Experience working in dynamic, productive, cross-functional internal and external teams
Outstanding organizational abilities with a collaborative, tactful, and goal-oriented working style

Why Join Us

Opportunity to work on cutting-edge ADC/AOC technologies.
Collaborative and dynamic work environment.
High-impact role with visibility across the organization.

About Lifordi

Lifordi Immunotherapeutics, Inc. is a clinical-stage biotechnology company leveraging the success of antibody-drug conjugates (ADCs) for the treatment of autoimmune and inflammatory disorders. The Company’s lead ADC, LFD-200, is designed to deliver a potent glucocorticoid (GC) directly to immune cells and is in a Phase 1 clinical trial for rheumatoid arthritis (RA). Preclinical studies demonstrated efficacy in multiple disease models by targeting myeloid and lymphoid cells using a highly internalized cell surface membrane protein (VISTA). Lifordi has also applied its novel drug delivery platform to other diverse payloads, such as small molecules, antisense oligonucleotides (ASOs) and siRNA. As experienced drug developers in immunology and inflammatory diseases, together with expert clinical advisors, a strong partnering track record, and funding from ARCH Venture Partners, 5AM Ventures, Atlas Venture, and Sanofi Ventures, Lifordi is committed to changing how immune and inflammatory diseases are treated.

For more information, please visit www.lifordi.com.

Industry

Biotechnology Research

Employment Type

Full-time, 6-to-9 months contract position (no guarantee of extension or transfer for FTE)
Healthcare benefits not included

Lifordi Immunotherapeutics, Inc.

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CONTRACT ROLE: Scientist, Discovery Immunology